It is an evergreen tree native to the Indian subcontinent, used in Ayurvedic medicine. The Azadirachta indica L (Neem) shows a therapeutic activity due to a rich variety of components including azadirachtin [1]. 


The components of Azadirachta indica exert useful pharmacological effects in the management of various pathologies through different action mechanisms, although antioxidant activity is outlined as one of the main [1].

The efficacy of Neem applied intra-vaginally versus placebo in HPV elimination in women with HPV 16 positive for HPV 16 with or without low-grade squamous lesions (LSIL) has been evaluated [2]. The results show an 80% of negativisation of HPV 16 compared to 10% with placebo, which is accompanied by an improvement of the symptomatology and cytology.


These results show that the intravaginal application of Neem may be effective in eliminating HPV infection.


1. Alzohairy M. Therapeutics Role of Azadirachta indica (Neem) and Their Activa Constituents in Diseases Prevention and Treatment. Evidence-Based Complementary and Alternative Medicine 2016 ID 7382506.  


2. Shukla S, et al. Elimination of high-risk human papilomavirus type HPV 16 infection by “Praneem” polyherbal tablet in women with early cervical intraepithelial lesions J. Cancer Res Clin Ocol (2009) 135: 1701-1709.