Figure 3.
Adapted from A. Amador-Molina Viruses 2013, 5, 2624-2642; doi:10.3390/v5112624

This strategy of HPV is mainly directed to down-regulate the pro-inflammatory response in cervical keratinocytes.

Figure 2.
Adapted from Maria Kyrgiou Translational Research DOI: (10.1016/j.trsl.2016.07.004)

The vaginal microbiota may play a functional role in the acquisition and persistence of HPV.

Figure 3:


The metaplasic squamous epithelium comes from differentiation and proliferation of reserve cells and is the perfect target for anchoring the HPV.

Figure 2: 


Effect of Papilocare® on cervical re-epithelialization  .

Figure 3: 

Colposcopic images of 3 patients before and after the application of Palomacare®, in which changes in the epithelization of the cervix are observed.


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2.  Moscicki AB, Schiffman M, Burchell A, Albero G, Giuliano AR, Goodman MT et al. Updating the natural history of human papillomavirus and anogenital cancers. Vaccine. 2012; 30Suppl 5:F24-33.


3. Torné A, del Pino M, Cusidó M, Alameda F, Andia D, Castellsagué X et al. Guía de Cribado del Cáncer de Cuello de Útero en España, 2014. Prog Obstet Ginecol 2014; 57(Supl. 1):1-53.


4. Reid JL, Wright TC Jr, Stoler MH, Cuzick J, Castle PE, Dockter J. et al. Human Papillomavirus Oncogenic mRNA Testing for Cervical Cancer Screening: Baseline and Longitudinal Results From the CLEAR Study. Am J Clin Pathol. 2015; 144:473-83.


5. Curso de Colposcopia de la Asociación Española de Patología Cervical y Colposcopia. Disponible en Acceso: 07/09/15.


6. Egawa N, Egawa K, Griffin H and Doorbar J. Human Papillomaviruses: Epithelial Tropisms and the Development of Neoplasia. Viruses. 2015; 7:3863-90.


7. Palacios S.: Pilot study to evaluate the effect of a Coriolus versicolor based vaginal gel on the epithelialization of the cervix lesions. Poster. 30th International Papillomavirus Conference. Septiembre 17-21, 2015. Lisboa. Portugal.