Figure 3.
Adapted from A. Amador-Molina Viruses 2013, 5, 2624-2642; doi:10.3390/v5112624

This strategy of HPV is mainly directed to down-regulate the pro-inflammatory response in cervical keratinocytes.

Figure 2.
Adapted from Maria Kyrgiou Translational Research DOI: (10.1016/j.trsl.2016.07.004)

The vaginal microbiota may play a functional role in the acquisition and persistence of HPV.

Figure 3:

 

The metaplasic squamous epithelium comes from differentiation and proliferation of reserve cells and is the perfect target for anchoring the HPV.

Figure 2: 

 

Effect of Papilocare® on cervical re-epithelialization  .

Figure 3: 

Colposcopic images of 3 patients before and after the application of Palomacare®, in which changes in the epithelization of the cervix are observed.

REFERENCIAS

1. Castellsagué X, Iftner T, Roura E, Vidart JA, Kjaer SK, Bosch FX et al. Prevalence and genotype distribution of human papillomavirus infection of the cervix in Spain: the CLEOPATRE study. J Med Virol. 2012;84:947-56.

2.  Moscicki AB, Schiffman M, Burchell A, Albero G, Giuliano AR, Goodman MT et al. Updating the natural history of human papillomavirus and anogenital cancers. Vaccine. 2012; 30Suppl 5:F24-33.

 

3. Torné A, del Pino M, Cusidó M, Alameda F, Andia D, Castellsagué X et al. Guía de Cribado del Cáncer de Cuello de Útero en España, 2014. Prog Obstet Ginecol 2014; 57(Supl. 1):1-53.

 

4. Reid JL, Wright TC Jr, Stoler MH, Cuzick J, Castle PE, Dockter J. et al. Human Papillomavirus Oncogenic mRNA Testing for Cervical Cancer Screening: Baseline and Longitudinal Results From the CLEAR Study. Am J Clin Pathol. 2015; 144:473-83.

 

5. Curso de Colposcopia de la Asociación Española de Patología Cervical y Colposcopia. Disponible en http://www.aepcc.org/ Acceso: 07/09/15.

 

6. Egawa N, Egawa K, Griffin H and Doorbar J. Human Papillomaviruses: Epithelial Tropisms and the Development of Neoplasia. Viruses. 2015; 7:3863-90.

 

7. Palacios S.: Pilot study to evaluate the effect of a Coriolus versicolor based vaginal gel on the epithelialization of the cervix lesions. Poster. 30th International Papillomavirus Conference. Septiembre 17-21, 2015. Lisboa. Portugal.